Adaptive Dunnett tests for treatment selection.

Maximum type 1 error rate inflation in multiarmed clinical trials with adaptive interim sample size modifications

Sample size modifications in the interim analyses of an adaptive design can inflate the type 1 error rate, if test statistics and critical boundaries are used in the final analysis as if no modification had been made. While this is already true for designs with an overall change of the sample size in a balanced treatment-control comparison, the inflation can be much larger if in addition a modi...

Asymptotic properties of the sample mean in adaptive sequential sampling with multiple selection criteria

‎We extend the method of adaptive two-stage sequential sampling to‎‎include designs where there is more than one criteria is used in‎‎deciding on the allocation of additional sampling effort‎. ‎These‎‎criteria‎, ‎or conditions‎, ‎can be a measure of the target‎‎population‎, ‎or a measure of some related population‎. ‎We develop‎‎Murthy estimator for the design that is unbiased estimators for‎‎t...

Multiple testing to establish superiority/equivalence of a new treatment compared with kappa standard treatments.

In this paper we develop multiple hypotheses testing procedures to compare a new treatment with a set of standard treatments in a clinical trial. The aim is to classify the new treatment with respect to each of the standards, by specifying those to which the new treatment is superior, those to which the new treatment is equivalent and those to which one can establish neither superiority nor equ...

Optimal Combined and Adaptive Protection of Active Distribution Networks Considering Different System Topologies Incorporating Optimal Selection of Standard Relay Curves

The change in the topology of active distribution networks (ADNs) is one of the essential challenges that might affect the protection schemes. The conventional protection schemes based on base topology result in some coordination constraint violations in other topologies due to the outage of upstream substations and distributed generation units. In this article, new combinational and adaptive p...

BIODEGRADATION OF TERT-BUTYL ALCOHOL (TBA) USING BIOLOGICAL GRANULAR ACTIVATED CARBON (BIO-GAC) BY KAYLEIGH ANNE DUNNETT THESIS Submitted in partial fulfillment of the requirements for the degree of Master of Science in Environmental Engineering in Civil Engineering